Nuclear Medicine — 2017-10-29

Click here for a pdf of the talk. The pdf includes live links.

The 4EEY structure from the RCS Protein Data Bank is available here

Reference:  Ummat, A., Rechkoblit, O., Jain, R., Roy Choudhury, J., Johnson, R.E., Silverstein, T.D., Buku, A., Lone, S., Prakash, L., Prakash, S., Aggarwal, A.K. , “Structural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy.”  Nat.Struct.Mol.Biol. 2012, 19: 628-632.

Here are links to the rotating or 3D structures made with JMOL:

Complete Structure

Just the protein part

Just the DNA part

A close-up of the PtCl2 group in just the DNA part.

The cross-eyed stereogram of the DNA part

Here is a link to the cross-eyed stereogram of the Yttrium complex  4311636 from crystallography.net:

Click here for link. Made with JMOL.

Reference: Wen-Yuan Hsieh; Shuang Liu, “Synthesis, Characterization, and Structures of Indium In(DTPA-BA2) and Yttrium Y(DTPA-BA2)(CH3OH) Complexes (BA = Benzylamine): Models for 111In- and 90Y-Labeled DTPA-Biomolecule Conjugates,” Inorganic Chemistry, 2004, 43, 6006-6014

Here is a link to the cross-eyed stereogram of the proposed Gadolinium MRI contrast.

Click here for link. Made with JMOL.

Reference: N. Raghunandet al “Design, synthesis, and evaluation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derived, redox-sensitive contrast agents for magnetic resonance imaging,” Journal of Medicinal Chemistry, 2010, 53, 6747-6757.

The talk should be available on YouTube soon.  The calendar of talks can be accessed through the Science Circle website.